| bcl-2和P 53在人脑胶质瘤中的表达及其与肿瘤分化的关系 |
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| 引用本文： | 胡苹,左焕琮,王泰龄.bcl-2和P 53在人脑胶质瘤中的表达及其与肿瘤分化的关系[J].中日友好医院学报,1999,13(2):87-89. |
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| 作者姓名： | 胡苹 左焕琮 王泰龄 |
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| 作者单位： | 中日友好医院中心实验室 |
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| 摘 要： | 目的：探讨ｂｃｌ２和Ｐ５３在人脑胶质瘤中的表达及其与肿瘤分化的关系。方法：采用免疫组化ＳＰ法对３５例人脑胶质瘤石蜡标本中ｂｃｌ２和Ｐ５３进行检测。结果：ｂｃｌ２和Ｐ５３蛋白在胶质瘤中的表达率分别为６５７％和３７％。ｂｃｌ２阳性表达主要位于分化较好的星形细胞瘤；而Ｐ５３蛋白表达主要位于分化差的间变性星形细胞瘤和多形性胶质母细胞瘤。Ｐ５３阳性表达与肿瘤恶性度和病理分型均呈正相关。结论：在分化较高的肿瘤中以ｂｃｌ２表达为主，而在低分化肿瘤中以Ｐ５３表达为主，二者在调节胶质瘤的形成与分化方面可能起重要作用
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| 关 键 词： | 神经胶质瘤 蛋白质P53 癌基因蛋白质类 免疫组织化学 |
BCL 2 AND P 53 EXPRESSION IN HUMAN BRAIN GLIOMAS AND ITS CORRELATION
WITH DIFFERENTIATION OF TUMORS |
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| Hu Ping,Zuo Huancong,Wang Tailing,et al.BCL 2 AND P 53 EXPRESSION IN HUMAN BRAIN GLIOMAS AND ITS CORRELATION
WITH DIFFERENTIATION OF TUMORS[J].Journal of China-Japan Friendship Hospital,1999,13(2):87-89. |
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| Authors: | Hu Ping Zuo Huancong Wang Tailing et al |
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| Institution: | Laboratory Centre;Department of Neurosurgery;Department of Pathology |
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| Abstract: | Objective:To investigate bcl 2 and P 53 protein expression in human brain
gliomas.Methods:Surgical specimens from 35 patients with human brain gliomas
underwent a routine fixation,embedment with paraffin and immunohistochemical staining
with a monoclonal antibody against P 53 protein and a polyclonal antibody against bcl
2.Results:Bcl 2 expression was positive in 65 7% of gliomas,and a positive P 53
expression in 37% was shown.Most astrocytoma was positive bcl 2 whereas most
anaplastic astrocytoma and glioblastoma multiply was positive P 53.Conclusion:Most
tumors of higher differentiation were showed positive bcl 2,whereas most tumors of
lower differentiation were in positive P 53,which may play an important role in
regulation of tumors differentiation. |
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| Keywords: | glioma protein P 53 oncogene proteins immunohistochemistry |
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