妊娠期高血压疾病妇女外周血调节性T细胞和辅助性T细胞表达分析

目的 分析妊娠期高血压疾病(PIH)妇女外周血调节性T细胞和辅助性T细胞表达变化。方法 连续选择近期住院确诊的PIH 妇女27例(PIH组)，入选对象均接受了外周血调节性T细胞(CD+4CD+25 Treg 和CD+4CD+25 Foxp3+Treg)和辅助性T细胞(CD+3、CD+4、CD+8、CD+4/CD+8)检测，并与同期住院正常怀孕产妇 (对照组，20例)相同测试结果进行比较。结果 调节性T细胞数据中，PIH组血清CD+4CD+25 Treg和CD+4CD+25 Foxp3+ Treg水平明显低于对照组(P均<0.05～0.01)。辅助性T细胞中，PIH组血清CD+4/CD+8表达水平明显高于对照组，而CD+8表达水平则显著低于对照组(P均<0.05～0.01)。结论 PIH患者存在明确的外周血调节性T细胞和辅助性T细胞异常表达。

Expression of regulatory T cells and helper T lymphocytes in the peripheral blood of pregnancy induced hypertension women

Objective To analyze expressions of regulatory T cells and helper T lymphocytes in the peripheral blood of pregnancy induced hypertension (PIH) women. Methods 27 PIH women were selected to detect regulatory T cells (CD+4CD+25 Treg and CD+4CD+25 Foxp3+Treg) and helper T lymphocytes (CD+3、CD+4、CD+8、CD+4/CD+8) in the peripheral blood, and the testing results were compared with another 20 normal pregnant women during the same hospitalization. Results Levels of CD+4CD+25 Treg and CD+4CD+25 Foxp3+ Treg of the regulatory T cells in the PIH women were significantly lower than those in the control group(P<0.05-0.01). Level of CD+4/CD+8 of helper T lymphocytes in the PIH women was significantly higher than that in the control group(P<0.05 0.01), but level of CD+8 in the PIH women was significantly lower than that in the control group (P<0.05-0.01). Conclusion It is clearly indicated that expressions of regulatory T cells and helper T lymphocytes in the peripheral blood of PIH women are out of the normal range.