类鼻疽病临床特征及耐药性分析——附122例报告

摘要 目的 分析类鼻疽病临床特征及其耐药性。方法 采用海南医学院附属医院，海南省人民医院及海口市人民医院各检验科细菌分离出的类鼻疽伯克霍尔德菌122株，回顾性的分析其临床表现，并采用VITEK-32微生物自动分析仪测定122株类鼻疽伯克霍尔德菌的药物敏感性。结果 肺部感染是类鼻疽病最常见的临床类型，本研究122例中有86例，占70%，主要临床特征有：农民或渔民、糖尿病基础疾病、、畏寒、发热、局部脓肿、肝脾淋巴结肿大、休克、败血症。类鼻疽伯克霍尔德菌对亚胺培南和美罗培南均无耐药，对其他药物均有不同程度的耐药，尤其是对妥布霉素的耐药率为100％。结论 类鼻疽病在海南地区广泛存在，有其特殊的临床表现，应加强基层医生对本病的认识，早期进行细菌学的检查，及早选用有效的抗生素具有重要的临床意义。

The Analysis of Clinical Characteristics and Drugs Resistances on Melioidosis: 122 Cases report.

Abstract] Objective:The analysis of clinical and the drugs resistance on Melioidosis. Method: Retrospective analysis the clinical symptom of 122 cases with Burkholderia Pseudomallei from Affiliated Hospital of Hainan Medical College, Hainan Provincial People,s Hospita（80443）l and Haikou City People,s Hospital, and strains of Burkholderia Pseudomallei isolated from clinical specimens were tested for susceptibility to antimicrobial agents by VITEK-32. Results: Pneumonia Is the common clinical types on Melioidosis. There are 86 cases in our reported. Farmers or Fishermen, background diseases( such as diabetes), chills, fever, hepatosplenomegaly, septic shock sepsis et al were the main causes of melioidosis. .The importance clinical are eresistance rates of Burkholderia Pseudomallei to Imipenem and meropenem were 0%. Other drugs have different levels of resistance to Tobramycin was 100% respectively. Conclusion: Melioidosis is widespread in Hainan. There are special clinicals. Strengthen recognize the disease to basic level priority measures are to enhance laboratory diagnosis rates of Burkholderia Pseudomallei and chosen effective drugs for treatment of infection as early as possible.