顺阿曲库胺不同给药方式对正常家兔运动诱发电位的影响

摘要 目的 观察顺阿曲库胺不同给药方式对正常家兔MEP影响。方法 选正常新西兰大白兔30只，随机分为3组，每组10只，A组为单次静脉推注0.08mg/kg，B组第一次静脉推注0.04mg/kg，半小时后再次静脉推注0.04mg/kg，C组微量泵持续泵入0.06mg／(kg•h)。分别记录给药前(T0)、给药后10(T1)、30(T2)、50(T3)、60(T4)、90min(T5)时家兔下肢MEP。结果 A、B两组家兔于用药后10min内MEP潜伏期逐渐延长，波幅逐渐下降，直至消失，但A组于用药后45-60分钟后恢复，B组家兔到实验结束未记录到运动诱发电位；C组家兔自始至终均成功记录到MEP。结论 用微量泵持续静脉泵人顺阿曲库铵优于单次静脉推注，较易成功监测家兔MEP。

cis atracurium different ways of administration effect on motor evoked potentials (MEP)of the normal rabbits

Objective To evaluate the effects of different methods of cis-atracurium administration on motor e-voked potential(MEP) in rabbits.Methods Thirty normal New Zealand rabbits were randomized into 3 groups(n = 10) according to administration of cis-atracurium: Group A(bolus intravenous injection of 0.08 mg/kg),Group B(initial intravenous injection of 0.04 mg/kg with another 0.04 mg/kg half an hour later),and Group C(intravenous micro-pump by 0.06 mg/kg.h).MEP in lower limb of each subject was recorded before a...