极低出生体重儿呼吸道分泌物解脲脲原体阳性与肺部损伤的关系

目的 探讨极低出生体重儿呼吸道分泌物解脲脲原体（UU）阳性与肺部损伤的关系。方法 选择2011年10月至2013年5月我院新生儿重症监护病房收治的极低出生体重儿,采用荧光定量聚合酶链反应法检测入院时呼吸道分泌物UU核酸,根据检测结果分为阳性组和阴性组。比较两组入院时感染标记物、新生儿呼吸窘迫综合征、先天性肺炎发生率的差异,以及住院时间28天以上者支气管肺发育不良发生率。结果 174例极低出生体重儿中,UU阳性69例,阴性105例;UU阳性组新生儿呼吸窘迫综合征发生率（26.1%,18/69）低于阴性组（56.2%,59/105）;先天性肺炎发生率（47.8%,33/69）高于阴性组（31.4%,33/105）;住院28天以上的VLBWI 145例,其中UU阳性56例,阴性89例,两组支气管肺发育不良发生率差异无统计学意义。而对于体重〈1250 g的极低出生体重儿,UU阳性组支气管肺发育不良发生率（74.1%,20/27）高于阴性组（45.0%,18/40）。结论 呼吸道分泌物UU阳性增加了极低出生体重儿先天性肺炎、出生体重〈1250 g的极低出生体重儿支气管肺发育不良的发生风险,是新生儿呼吸窘迫综合征的保护性因素。

Study on relationship between ureaplasma urealyticum in the respiratory tract of very low birth weight infants and lung injury

Objective To explore the relationship between ureaplasma urealyticum （UU） in the respiratory tract of very low birth weight infants and lung injury. Methods UU can be detected by using fluorescence quantitative polymerase chain reaction in airway secretions. 174 very low birth weight infants were divided into the positive group （ n = 69） and the negative group （ n = 105 ） based on the result of the PCR result. Infection markers and the rate of respiratory distress syndrome （RDS） and congenital pneumonia were compared in two groups. In 145 infants who were hospitalized for more than 28 days, the rate of bronehopulmonary dysplasia （BPD） was also compared. Results Out of 174 patients, the rate of RDS in UU positive group （26. 09% ,18/69） was lower than the negative （56. 19% ,59/105） and the rate of congenital pneumonia in UU positive group （47. 83% ,33/69） was higher than the negative （31.43%, 33/105）. Out of 145 patients, hospitalized for more than 28 days, the rate of BPD had no difference.However, among the infants （BW 〈 1250 g）,the incidence of BPD in UU positive group（74. 07% ,20/27） was higher （X2 = 5. 550, P = 0. 018 ）. Conclusions UU in the respiratory tract increased the risk of congenital pneumonia in very low birth weight infants; UU increased the risk of BPD in infants of birth weight less than 1250 g. Overall, there was a decreased the risk of RDS in UU positive infants.