The role of mannose in the receptor of the monocyte locomotion inhibitory factor produced byEntamoeba histolytica |
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| Authors: | R. R. Kretschmer E. M. Castro G. Pacheco G. Rico O. Diaz-Guerra J. Arellano |
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| Affiliation: | (1) Division of Immunology, Unidad de Investigación Biomédica del Centro Médico Nacional, Instituto Mexicano del Seguro Social and Subdivisión de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, México |
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| Abstract: | The effect of the monocyte locomotion inhibitory factor (MLIF) produced byEntamoeba histolytica is diminished, if not cancelled, when human monocytes are pre-exposed to concanavalin A or sodium periodate, respectively, but not when MLIF is pretreated with sodium periodate. When the MLIF-inhibited monocyte locomotion assays were performed in the presence of 12 different carbohydrates, only the runs containingd-mannose, 4-O- -galactorsyl-mannoside or mannan revealed a significant reduction in the inhibitory effect. Finally, the MLIF activity was virtually absorbed out with mannan-coupled Sepharose 4B beads. This suggests thatd-mannose constitutes an essential part of the receptor for MLIF on the human monocyte membrane. |
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