Induction of beta-chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions |
| |
Authors: | Omari Kakuri M Chui Raymond Dorovini-Zis Katerina |
| |
Institution: | Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, 855 West 12th Avenue, Vancouver, BC, Canada V5Z 1M9. |
| |
Abstract: | beta-chemokines play an important role during the course of central nervous system (CNS) inflammation. Using primary cultures of human cerebral microvascular endothelial cells, we detected increased monocyte chemoattractant protein-1 (MCP-1) and regulated upon activation normal T cell expressed and secreted (RANTES) production following incubation with soluble CD40L. These results suggest a potential mechanism by which activated CD40L positive T cells may enhance beta-chemokine expression and thus influence the recruitment of mononuclear cells across the human blood-brain barrier. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|