| 海马内M1和M2受体与学习记忆关系的研究 |
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| 引用本文： | 王向兵,段世明,周文华,杨国栋. 海马内M1和M2受体与学习记忆关系的研究[J]. 徐州医学院学报, 2004, 24(2): 126-129 |
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| 作者姓名： | 王向兵 段世明 周文华 杨国栋 |
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| 作者单位： | 1. 徐州医学院江苏省麻醉医学研究所,江苏,徐州,221002
2. 宁波微循环与莨菪类药研究所宁波市戒毒研究中心,浙江,宁波,315010 |
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| 摘 要： | 目的 研究海马内M1和M2受体亚型对学习记忆的调节。方法 SD大鼠分为3组，海马内分别微重注射M1、M2反义寡核苷酸(MASODN)，以海马内注射生理盐水作为对照组，观察药物对大鼠被动逃避反应步入潜伏期的影响。结果 海马内注射M2ASODN大鼠的步入潜伏期显著缩短，较对照组减少75％，海马内注射M2ASODN大鼠的步入潜伏期显著延长。结论 海马内M1受体可正向调节学习记忆，而M2受体负向调节学习记忆。
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| 关 键 词： | 海马 M2受体 M1受体 学习记忆功能 胆碱能系统 大鼠 |
| 文章编号： | 1000-2065(2004)02-0126-04 |
The study of M1 and M2 receptors in hippocampus associated with learning and memory |
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| WANG Xiang-bing,DUAN Shi-ming,ZHOU Wen-hua,et al. The study of M1 and M2 receptors in hippocampus associated with learning and memory[J]. Acta Academiae Medicinae Xuzhou, 2004, 24(2): 126-129 |
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| Authors: | WANG Xiang-bing DUAN Shi-ming ZHOU Wen-hua et al |
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| Abstract: | Objective To investigate the effects of M 1 and M 2 muscarinic receptors in the hippocampus on the latency of step-through inhibitory avoidance task. Methods Eighteen adult male SD rats were divided into three groups (n=6 each). Steel guide cannulas aimed at the hippocampus were implanted; bilateral infusion of M 1 or M 2 ASODN (antisense oligodeoxynucleotides) was given 16 hours prior to the training and testing of step-through inhibitory avoidance task. Results Intrahippocampal injection of M 1 ASODN impaired the retention of memory for inhibitory avoidance, while intrahippocampal injection of M 2 ASODN facilitated the fear-activated memory. Conclusion M 1 and M 2 muscarinic receptors modulate learning and memory, with M 1 receptors enhancing and M 2 receptors suppressing learning and memory. |
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| Keywords: | antisense oligonucleotide muscarinic receptor hippocampus learning and memory |
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