| RNAi技术在抑制血管平滑肌细胞增殖中的研究进展 |
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| 引用本文： | 刘苏健,邓勇志. RNAi技术在抑制血管平滑肌细胞增殖中的研究进展[J]. 心血管病学进展, 2007, 28(4): 620-622 |
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| 作者姓名： | 刘苏健 邓勇志 |
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| 作者单位： | 山西医科大学第二医院心胸外科,山西,太原,030001 |
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| 摘 要： | 移植血管狭窄是影响冠脉旁路移植术后远期疗效的主要原因,其机理包括血管中膜平滑肌细胞表型转化、增殖、迁移至内膜并合成大量的细胞外基质。RNA干扰(RNAi)技术是一种沉默特异基因序列的基因治疗方法,现对其机理及在抑制血管平滑肌细胞增殖中的应用进展进行综述。
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| 关 键 词： | 移植血管狭窄 血管平滑肌细胞 增殖 |
| 文章编号： | 1004-3934（2007）04-0620-03 |
| 修稿时间： | 2006-09-132006-11-27 |
Advances of RNA Interference for Inhibiting VSMC Hyperplasia |
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| LIU Su-jian,DENG Yong-zhi. Advances of RNA Interference for Inhibiting VSMC Hyperplasia[J]. Advances in Cardiovascular Diseases, 2007, 28(4): 620-622 |
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| Authors: | LIU Su-jian DENG Yong-zhi |
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| Affiliation: | Department of Cardiothoracic Surgery, The Second Teaching Hospital of Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Vein graft stenosis is a leading cause of graft failure in coronary artery bypass grafting surgery. Its mechanism includes media vascular smooth muscle cell (VSMC) phenotypical modulation,proliferation,migration to the intima and synthesis large number of extracellular matrix. RNA interference technology is a gene therapy which can silence special gene sequences. This paper reviews the principle of RNAi technology and its application advances in the field for inhibiting VSMC hyperplasia. |
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| Keywords: | RNAi |
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