| 尿囊素凝胶的制备及含量测定 |
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| 引用本文： | 邵珠民,吕冬梅,王涛,韩强. 尿囊素凝胶的制备及含量测定[J]. 中国药房, 2007, 18(28): 2205-2207 |
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| 作者姓名： | 邵珠民 吕冬梅 王涛 韩强 |
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| 作者单位： | 徐州医学院附属医院药剂科,徐州市,221002 |
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| 摘 要： | 目的:制备尿囊素凝胶并建立其含量测定方法。方法:以尿囊素为主药,卡波姆-940为基质制备凝胶;采用高效液相色谱法测定其中主药含量。结果:所制凝胶涂展性好;尿囊素检测浓度的线性范围为12.78～68.16μg.mL-1(r=0.9999),平均回收率为99.7%(RSD=0.36%)。结论:本制剂制备工艺简便可行,含量测定方法准确、快速,可用于该制剂的质量控制。
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| 关 键 词： | 尿囊素 凝胶 制备 含量测定 |
| 文章编号： | 1001-0408（2007）28-2205-03 |
| 收稿时间： | 2007-01-23 |
| 修稿时间： | 2007-03-06 |
Preparation and Content Determination of Allantoin Gel |
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| SHAO Zhumin,LU Dongmei,WANG Tao,HAN Qiang. Preparation and Content Determination of Allantoin Gel[J]. China Pharmacy, 2007, 18(28): 2205-2207 |
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| Authors: | SHAO Zhumin LU Dongmei WANG Tao HAN Qiang |
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| Abstract: | OBJECTIVE:To prepare allantoin gels and to determine its content.METHODS:The gels were prepared with allantoin as principal agent and carbomer-940 as gel base.The content of the principal agent was determined by HPLC.RESULTS:The prepared product was proved to be well-spread.The linear range of allantoin was 12.78～ 68.16μ g· mL-1(r=0.999 9),with average recovery rate at 99.7%(RSD=0.36%).CONCLUSIONS:The preparation process of allantoin gels is simple and feasible,and the established content determination method is rapid and accurate,and it can be used for quality control of this preparation. |
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| Keywords: | Allantoin Gel Preparation Content determination |
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