| 髓过氧化物酶基因-463 G>A多态性与早发冠心病的相关性 |
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| 引用本文： | 殷泉忠,陈忠,张华,郑若龙,王加红,高春恒,王东升,马根山.髓过氧化物酶基因-463 G>A多态性与早发冠心病的相关性[J].江苏医药,2008,34(10). |
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| 作者姓名： | 殷泉忠 陈忠 张华 郑若龙 王加红 高春恒 王东升 马根山 |
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| 作者单位： | 1. 东南大学附属江阴医院心脏病科,江阴,214400
2. 南京,东南大学附属中大医院心脏病科、心血管病研究所 |
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| 摘 要： | 目的 探讨髓过氧化物酶(MPO)基因-463 G＞A多态性与早发冠心病(CHD)的相关性.方法 早发CHD 134例,对照145例,采用LDR-PCR测序分型技术分析两组患者MPO基因启动子区第-463位核苷酸多态基因型分布,及其与早发CHD的关系.结果 病例组A/A基因型及A等位基因频率低于对照组,病例组G/G基因型及G等位基因频率高于对照组.杂合子G/A在两组患者中差异无统计学意义.等位基因A对早发CHD易感性的保护作用有统计学意义(P＜0.01).携带至少一个等位基因A的患者早发CHD的发病风险降低达50%(OR=0.50,95%CI:0.27～0.93),A/A基因型的患者早发CHD的发病风险降低达89%(OR=0.11,95%CI:0.03～0.40).结论 MPO-463 G＞A基因多态性与早发冠心病的发病风险相关,MPO-463 A等位基因携带者患早发冠心病的风险明显降低.
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| 关 键 词： | 髓过氧化物酶 冠心病 基因型 多态性 遗传学 |
Relationship between myeloperoxidase gene-463 G>A polymorphism and premature coronary heart disease |
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| YIN Quanzhong,CHEN Zhong,ZHANG Hua,et al..Relationship between myeloperoxidase gene-463 G>A polymorphism and premature coronary heart disease[J].Jiangsu Medical Journal,2008,34(10). |
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| Authors: | YIN Quanzhong CHEN Zhong ZHANG Hua |
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| Institution: | YIN Quanzhong,CHEN Zhong,ZHANG Hua,et al.Department of Cardiology,Affiliated Jianyin Hospital,Southeast University,Jianyin 214400,CHINA |
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| Abstract: | Objective To investigate the relationship between premature coronary heart disease(CHD) and genetic polymorphism at nucleotide-463 G>A in myeloperoxidase(MPO).Methods The association of MPO gene polymorphism with premature coronary heart diease in a hospital-based case-control study of 134 patients and 145 age-and sex-matched controls was tested.MPO genotypes were determined by ligase detection reaction-PCR sequencing and grouping technique.Results The A/A genotype and A allele were significantly lower in c... |
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| Keywords: | Myeloperoxidase Coronary artery disease Genotype Polymorphism Genetics |
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