Expression of genes for interleukin-1 alpha and tumour necrosis factor-alpha in newborn mice. |
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| Authors: | M Lipoldov V Hol n |
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| Affiliation: | Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague. |
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| Abstract: | Spleen cells from newborn mice are immunologically non-reactive and do not respond by proliferation to T- or B-cell mitogens. However, they synthesize significant levels of mRNA for interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) after mitogen stimulation. Since these two cytokines mediate many protective activities in the body, they may be important in ensuring the survival of immunologically immature newborns. |
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