妊娠糖尿病患者血浆视黄醇结合蛋白4水平与胰岛素抵抗的相关性分析

目的检测妊娠糖尿病患者血浆视黄醇结合蛋白4（RBP4）的水平，探讨其与胰岛素抵抗的关系。方法用酶联免疫分析法测定37例正常妊娠妇女及40例妊娠糖尿病患者血浆RBP4水平，同时测定空腹血糖、血脂及胰岛素水平，并计算稳态模型胰岛素抵抗指数（HOMA—IR）。结果妊娠糖尿病患者血浆RBP4水平（28．52±12．45）μg／mL]虽低于正常妊娠妇女组（31．47±14．28）μg／mL]，但差异无统计学意义（P〉0．05）。RBP4与HOMA—IR、空腹血糖呈正相关相关系数（r）分别为0．34、0．37，P〈0．05]。结论妊娠糖尿病患者空腹RBP4水平有下降的趋势但没有显著变化。RBP4水平与空腹血糖、HOMA—IR有关。

Relationship between retinol-binding protein-4 and insulin resistance in gestational diabetes mellitus

Objective To investigate the correlation between retinol-binding protein-4 （RBP4） level and insulin resistance in gestational diabetes mellitus （GDM）. Methods The levels of plasma RBP4 in 40 pregnant women with GDM and 37 normal pregnant women were determined by enzyme-linked immunosorbent assay （ELISA）. The levels of fasting blood glucose, insulin, total cholesterol and triglyceride were determined, and homeostasis model assessment insulin resistance index （HOMA-IR） was calculated. Results The plasma RBP4 level had no significant difference between GDM patients （28.52 ± 12.45） μg/mLl and normal pregnant women （31.47 ± 14.28）μg/mL] （P 〉 0.05 ）. In the GDM patients, RBP4 level was positively correlated with fasting blood glucose （ r = 0.37, P 〈 0.05 ） and HOMA-IR（r = 0.34, P 〈 0.05）. Conclusions The level of plasma RBP4 in GDM patients has decreasing tendency, but has no significant difference. The level of plasma RBP4 is correlated with HOMA-IR and fasting blood glucose.