Radiofrequency ablation of small breast tumours: Evaluation of a novel bipolar cool-tip application |
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Authors: | L. Waaijer D.L. Kreb M.A. Fernandez Gallardo P.S.N. Van Rossum E.L. Postma R. Koelemij P.J. Van Diest J.H.G.M. Klaessens A.J. Witkamp R. Van Hillegersberg |
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Affiliation: | 1. Department of Surgery, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands;2. Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands;3. Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands;4. Department of Surgery, St. Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands;5. Department of Medical Technology and Clinical Physics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands |
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Abstract: | BackgroundAlthough radiofrequency ablation (RFA) is promising for the local treatment of breast cancer, burns are a frequent complication. The safety and efficacy of a new technique with a bipolar RFA electrode was evaluated.MethodsDosimetry was assessed ex vivo in bovine mammary tissue, applying power settings of 5–15 W with 10–20 min exposure and 3.0–12.0 kJ to a 20-mm active length bipolar internally cooled needle-electrode. Subsequently, in 15 women with invasive breast carcinoma ≤2.0 cm diameter ultrasound-guided RFA was performed followed by immediate resection.ResultsAn ablation zone of 2.5 cm was reached in the ex vivo experiments at 15 W at 9.0 kJ administered energy. Histopathology revealed complete cell death in 10 of 13 patients (77%); in 3 patients partial ablation was due to inaccurate probe positioning. In 1 patient a pneumothorax was caused by the probe placement, treated conservatively. No burns occurred.ConclusionsUltrasound-guided RFA with a bipolar needle-electrode appears to be a safe local treatment technique for invasive breast cancer up to 2 cm. Ways to improve placement of the probe and direct monitoring of the ablation-effect should be the aim of further research. |
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Keywords: | Breast cancer Minimally invasive techniques Radiofrequency ablation (RFA) |
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