| 热灼伤致家兔角膜新生血管形成动物模型研制及皮质激素对其的抑制作用 |
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| 引用本文： | 白晋,陈国民.热灼伤致家兔角膜新生血管形成动物模型研制及皮质激素对其的抑制作用[J].眼科研究,1996(2). |
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| 作者姓名： | 白晋 陈国民 |
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| 作者单位： | 重庆医科大学第二医院!630010 |
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| 摘 要： | 在热灼伤致家兔角膜新生血管形成动物模型研制中，观察到热灼伤家兔角膜产生类似炎症反应的现象，并从肉眼观察和病理上证实了热灼伤可刺激角膜新生血管的增生。从角膜缘增生的新生血管于第5～7天达到和覆盖灼伤面，20天后基本消退。醋酸可的松可明显地抑制新生血管增生现象。证明此法简单易行。为临床探索抗角膜新生血管药物的研究提供了可靠的实验动物模型。
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| 关 键 词： | 家兔角膜 角膜灼伤 新生血管 |
Thermally Induced Neovascularization of Rabbit Corneas and the Suppressive Effects of Prednisone |
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| Bai Jin and Chen Guomin.Thermally Induced Neovascularization of Rabbit Corneas and the Suppressive Effects of Prednisone[J].Chinese Ophthalmic Research,1996(2). |
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| Authors: | Bai Jin and Chen Guomin |
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| Abstract: | In 24 rabbits with bilateral corneal burns,the process of corneal neovascularization was investigated. Af ter a corneal burn an inflammatory response was confirmed. The new blood vessels from the corneoscleral limbus reached and covered the burnt area in 5~7 days,and gradually regressed after 20 days. Topical treat ment with prednisone suppressed this neovascularization. The experiment showed a simple and valuable method for screening anti-angiogenic drugs with potential clinical use in the cornea |
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| Keywords: | rabbit corneas corneal burns neovascularization |
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