急性心肌梗死和急性脑梗死黏附分子及相关因素的对比研究

目的：探讨急性心肌梗死和急性脑梗死时黏附分子、血小板第4因子（PF4）和D－二聚体（DD）的临床意义。方法：分析对30例急性心肌梗死（AMI组）、23例急性脑梗死（ACI组）患者外周血的可溶性细胞间黏附分子－1（sICAM-1)、可溶性血管细胞黏附分子－1（sVCAM-1)、D二聚体、血小板第4因子工与健康对照组进行比较。结果：AMI组及ACI组在发病24h内及发病1周时血清sICAM-1、sVCAM-1、DD、PF4值均显著高于对照组（均P＜0.01），AMI组在发病1周时以上各值均高于ACI组（P＜0.01或P＜0.05）。结论：在心肌梗死和脑梗死发病初期及发病1周时，sICAM－1、sVCAM－1、DD、PF4相互作用共同参与急性血栓形成过程，为早期使用抗黏附分子抗体及药物治疗提供临床实验依据。

Clinical Significance of Adhesive Molecule and Its Relative Factors in Patients with Acute Myocardial Infarction and Acute Cerebral Infarction

Objective: To explore the clinical significances of adhesive molecule and its relative factors in patients with acute myo-cardial infarction (AMI) or acute cerebral infarction (ACI). Methods: The scrum solvable intercellular adhesion molecule-1 (sICAM-1 ), solvable vascular cell adhesion molecule-1 (sVCAM-1), D-dimer (D-D) and platelet factor 4 (PF4) were measured in 30 patients with AMI, 23 patients with AC I and 30 healthy controls. Results: The levels of serum sICAM-1 , sVCAM-1 , D-D and PF4 from 24 hours to one week in AMI and ACI groups were significantly higher than those in control group (P<0.001). In one week, the levels in AMI group were higher than those in ACI group (P<0.01 or 0.05). Conclusion: The levels of serum sICAM-1 , sVCAM-1 , D-D and PF4 in AMI and ACI continuously increase from 24 hours to one week, which takes part in acute thrombotic process. The use of anti-adhesion molecular antibody and drug may prevent or relief the process.