原发性高血压患者伴左心室肥厚与室性早搏的心率变异性及可达龙干预的探讨

目的 探讨原发性高血压(EH)患者伴左心室肥厚(LVH)与室性早搏(VPBS)的心率变异性(HRV)特点及可达龙对其治疗效果.方法 对108例EH患者伴或不伴LVH及室性早搏和80例正常人24h动态心电图(Holter)和心脏超声资料进行对比分析;频发VPBS组服用可达龙治疗6周后复查HRV,并与治疗前相比较.结果 EH患者伴LVH组的室性早搏发生率明显高于非LVH组与对照组(P＜0.05);非LVH组与对照组室性早搏的发生率无显著性差异(P＞0.05);2组患者心率变异性各指标差异无统计学意义(P＞0.05),但均明显低于对照组(P＜0.05);服用可达龙8周后HRV较治疗前明显改善(P＜0.05).结论 EH患者心率变异性与左心室肥厚的程度呈负相关,与心律失常的发生呈正相关;可达龙治疗可改善高血压伴室性早搏的HRV,改善其预后.

Clinical research of the relationships among left ventricular hypertrophy,ventricular premature beats and heart rate variability in patients with essential hypertension

Objective To analyze the relationships among left ventricular hypertrophy(LVH), ventricular premature beats(VPBS)and heart rate variability(HRV)in patients with essential hypertension(EH). Methods 108 EH patients complicated with LVH and NLVH and 80 normal controls received examinations by 24 hours Holter monitoring electrocardiogram. Results Both of the incidence and grades of ventricular premature beats for 24 hours in LVH group were obviously higher than that in control group. The parameters of HRV were not significantly different between the two groups(P>0.05). Conclusion The incidence of severe ventricular arrhythmia in EH patients with LVH raises obviously,but no correlativity exists between LVH and HRV.