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甲泼尼龙和地塞米松治疗大鼠液压冲击脑损伤的对比研究
引用本文:张兴光,季泰令,王目纲.甲泼尼龙和地塞米松治疗大鼠液压冲击脑损伤的对比研究[J].成都医学院学报,2011,6(1):52-54.
作者姓名:张兴光  季泰令  王目纲
作者单位:张兴光,季泰令,ZHANG Xing-guang,JI Tai-ling(潍坊医学院附属医院神经外科,山东,潍坊,261031);王目纲,WANG Mu-gang(河北医科大学第二医院神经外科,河北,石家庄,050000)
摘    要:目的 研究甲泼尼龙琥珀酸钠和地塞米松在成年大鼠液压冲击脑损伤中的疗效比较.方法 将29只SD大鼠随机分为两组,A创伤组(n=9)和B治疗组(n=20),B组又分为B1甲泼尼龙琥珀酸钠组(n=10)和B2地塞米松组(n=10).利用液压冲击脑损伤装置建立液压冲击脑损伤模型,A组损伤后不给予特殊处理.B组于损伤1 h、12...

关 键 词:地塞米松  甲泼尼龙  脑损伤

Comparison of methylprednisolone and dexamethasone in treatment of fluid percussion brain injury in rats
Authors:ZHANG Xing-guang  JI Tai-ling  WANG Mu-gang
Institution:1.Department of Neurosurgery,Affiliated Hospital of Weifang Medical College,Weifang,Shandong 261031,China;2.Department of Neurosurgery,The Second Hospital of Hebei Medical University,Shijiazhuang,Hebei 050000,China)
Abstract:Objective To compare the effect of methylprednisolone sodium succinate(MPSS)and dexamethasone in treating fluid percussion brain injury in adult rats.Methods twenty-nine adult sprague-dawley rats were randomly divided into group A(trauma,n=9)and group B(n=20),which was subdivided into B1(n=10)and B2(n=10)which MPSS or dexamethasone was given 1,12 and 24hr after fluid percussion brain injury.The cerebral injury of all rats was established by the fluid percussion method.Brain water content 72hr after brain injury was determined by the wet and dry weighing method.Single cell suspension was prepared with mechanical method.The florescent intensities for CD11b were analyzed by flow cytometry.Results As far as brain water content and the florescent intensities of CD11b,group A was significantly higher than groups B(P0.05),and group B2 was higher than group B1(P0.05).Conclusion MPSS is more effective than dexamethasone in suppressing cerebral edema and over-activation of microglia/macrophages.
Keywords:dexamethasone  methylprednisolone  brain injury
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