D-penicillamine in the treatment of eosinophilic fasciitis: case reports and review of the literature |
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Authors: | CU Manzini M Sebastiani D Giuggioli A Manfredi M Colaci AM Cesinaro C Ferri |
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Affiliation: | (1) Rheumatology Unit, Department of Internal Medicine, University of Modena e Reggio Emilia, Medical School, Via del Pozzo, 71, 41121 Modena, Italy;(2) Anatomia e Istologia Patologica, University of Modena e Reggio Emilia, Medical School, Modena, Italy; |
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Abstract: | Eosinophilic fasciitis (EF) is a rare disease characterized by symmetrical thickness and hardening of the skin, especially localized to forearms and thorax, with eosinophilia. Corticosteroids represent the first-line therapy, even if some patients are scarcely responsive and/or may develop important side effects due to long-term treatment. Here, we describe three cases of EF, two of them refractory to previous steroid therapy, successfully treated with D-penicillamine. The present clinical observations together with the updated review of the literature suggest usefulness of D-penicillamine in EF patients, as well as its potential steroid-sparing value. |
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