| 4-吡啶丁醇的合成 |
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| 引用本文： | 李宏名,邹平,李冰健,杜建成,翁少卿.4-吡啶丁醇的合成[J].中国新药杂志,2012(15):1803-1805. |
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| 作者姓名： | 李宏名 邹平 李冰健 杜建成 翁少卿 |
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| 作者单位： | 中国医药集团总公司四川抗菌素工业研究所;海门慧聚药业有限公司;国药集团工业有限公司廊坊分公司 |
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| 摘 要： | 目的:合成4-吡啶丁醇。方法:以4-溴吡啶盐酸盐为原料,经缩合、成盐、催化氢化再游离共4步反应得到目标产物。结果与结论:目标产物的化学结构经1HNMR确证,反应条件温和,操作简单,适宜工业化生产,总收率65.1%。
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| 关 键 词： | 替罗非班 4-吡啶丁醇 中间体 合成 |
Synthesis of 4-pyridinylbutanol |
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| LI Hong-ming,ZOU Ping,LI Bing-jian,DU Jian-cheng,WENG Shao-qing.Synthesis of 4-pyridinylbutanol[J].Chinese Journal of New Drugs,2012(15):1803-1805. |
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| Authors: | LI Hong-ming ZOU Ping LI Bing-jian DU Jian-cheng WENG Shao-qing |
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| Institution: | 1 Sichuan Industrial Institute of Antibiotics,China National Pharmaceutical Group Corporation, Chengdu 610052,China;2 Haimen Wisdom Pharmaceutical Co.,Ltd.,Haimen 226100,China; 3 China National Pharmaceutical Industry Co.,Ltd.,Langfang Branch,Langfang 065001,China) |
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| Abstract: | Objective: To synthesize 4-pyridinylbutanol.Methods: The target compound was prepared from 4-bromopyridine hydrochloride via 4 steps,including condensation,salification,hydrolysis and basification.Results and Conclusion: The chemical structure of the target compound was confirmed by 1H-NMR.All the raw materials are conveniently obtained and the reaction condition is comfortable for industrial manufacture.The total yield was 65.1% after applying the improved process. |
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| Keywords: | tirofiban 4-pyridinylbutanol intermediate synthesis |
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