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Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C |
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| Authors: | Yoon Joonho Lee Jong In Baik Soon Koo Lee Kwang Ho Sohn Joon Hyung Lee Hyean Woo Namkung Jun Chang Sei Jin Choi Jong Whan Kim Hyun Won Yeh Byung-Il |
| Affiliation: | 1. Department of Biochemistry and Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea 2. Department of Internal Medicine,Wonju College of Medicine, Yonsei University, Wonju 220-701,Republic of Korea 3. Department of Internal Medicine,Wonju College of Medicine, Yonsei University, Wonju 220-701,Republic of Korea;Institute of Lifelong Health, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea 4. Department of Anesthesiology, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea 5. Department of Biochemistry and Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea;Institute of Lifelong Health, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea 6. Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea;Institute of Lifelong Health, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea |
| Abstract: | AIM: To confirm the predictive factors for interferon (IFN)-alpha and ribavirin combination therapy for chronic hepatitis patients with hepatitis C virus (HCV) genotype 1b. METHODS: HCV RNA from 50 patients infected with HCV genotype 1b was studied by cloning and sequencing of interferon sensitivity determining region (ISDR), PKR-eIF2alpha phosphorylation homology domain (PePHD). Patients were treated with IFN-alpha and ribavirin for 6 mo and grouped by effectiveness of the therapy. A variety of factors were analyzed. RESULTS: Our data showed that age, HCV RNA titer, and ISDR type could be used as the predictive factors for combined IFN-alpha and ribavirin efficacy. Characteristically, mutations in PePHD appeared only when the combination therapy was effective. Other factors, such as sex and alanine aminotransferase (ALT) level, were not related to its efficacy. Adjusting for age and HCV RNA titer indicated that the ISDR type was the most potent predictive factor. CONCLUSION: HCV RNA ISDR type is an important factor for predicting efficacy of IFN-alpha and ribavirin combination therapy in Korean patients. |
| Keywords: | Hepatitis C virus -1b Ribavirin Interferon sensitivity determining region |
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