| 美托洛尔对舒张性心力衰竭兔神经内分泌系统的影响 |
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| 引用本文： | 蔡毅,范利,何昆仑,闫丽辉,冷文修.美托洛尔对舒张性心力衰竭兔神经内分泌系统的影响[J].军医进修学院学报,2010,31(2):175-177. |
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| 作者姓名： | 蔡毅 范利 何昆仑 闫丽辉 冷文修 |
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| 作者单位： | 解放军总医院南楼综合外二科,北京,100853 |
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| 基金项目： | 北京市自然科学基金面上项目(7052063);;全军“十·五”课题资助项目 (04T6002)~~ |
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| 摘 要： | 目的研究美托洛尔对舒张性心力衰竭兔神经内分泌系统的影响。方法雄性新西兰兔30只随机分为3组：手术组在右侧肾动脉上1cm处行腹主动脉缩窄术；手术治疗组从术后第1天起应用美托洛尔治疗；假手术组作为对照组。术后观察心衰的临床表现，定期复查超声心动图，并监测全身和心肌局部AngⅡ、ET-1、NE和NT—proBNP变化。结果手术治疗组的心衰发生率明显低于手术组，心室结构和功能达到显著改善，血清AngⅡ（25．57vs38．16，P〈0．01）、ET-1（21．14vs35．96，P〈0．01）和血清与心肌NE（97．90vs128．51，P〈0．01；11．77vs17．28，P〈0．05）、NT—proBNP（221．92vs305．76，P〈0．01；24．33vs30．53，P〈0．05）显著降低。结论美托洛尔可有效抑制DHF兔的全身和心肌局部神经内分泌系统激活.
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| 关 键 词： | 美托洛尔 心力衰竭，舒张性 兔 神经内分泌 |
Effect of metoprolol on neuroendocrine system of rabbits with diastolic heart failure |
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| CAI Yi,FAN Li,HE Kan-lun,YAN Li-hui,LENG Wen-xiu.Effect of metoprolol on neuroendocrine system of rabbits with diastolic heart failure[J].Academic Journal of Pla Postgraduate Medical School,2010,31(2):175-177. |
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| Authors: | CAI Yi FAN Li HE Kan-lun YAN Li-hui LENG Wen-xiu |
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| Institution: | CAI Yi,FAN Li,HE Kun-lun,YAN Li-hui,LENG Wen-xiu Second Department of South Building Comprehensive Surgery,Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | Objective To study the effect of metoprolol on neuroendocrine system of rabbits with diastolic heart failure.Methods Thirty New-Zealand rabbits were randomly assigned to operation group with constriction of abdominal aorta 1cm just above the right renal artery,treatment group receiving metoprolol from the first day after operation,and sham operation group serving as a control group.Changes in clinical manifestations of heart failure were carefully observed.Cardiac structure and function were investigated by... |
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| Keywords: | Metoprolol Heart Failure Diastolic Rabbits Neuroendocrine |
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