Vaccine assembly from surface proteins of Staphylococcus aureus |
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Authors: | Stranger-Jones Yukiko K Bae Taeok Schneewind Olaf |
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Affiliation: | Department of Microbiology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA. |
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Abstract: | Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of antibiotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, SdrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates. |
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