| 抗聚合人血清白蛋白的抗独特型抗体 |
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| 引用本文： | 李明远,王道若,牟家琬,蔡美英,刘文方,余蓉,刘晓宇. 抗聚合人血清白蛋白的抗独特型抗体[J]. 免疫学杂志, 1989, 0(4) |
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| 作者姓名： | 李明远 王道若 牟家琬 蔡美英 刘文方 余蓉 刘晓宇 |
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| 作者单位： | 华西医科大学微生物学教研室，华西医科大学微生物学教研室，华西医科大学微生物学教研室，华西医科大学微生物学教研室，中国医学科学院输血研究所，中国医学科学院输血研究所，中国医学科学院输血研究所 成都，成都，成都，成都 |
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| 摘 要： | 一种针对兔抗聚合人血清白蛋白抗体(anti-PHSA,Ab_1)的抗独特型抗体(anti-anti-PHSA,Ab_2),已通过免疫同种动物制成。该Ab_2具有以下特性:(1)它既可与兔anti-PHSA反应,也可与鼠的单克隆的anti-PHSA反应。(2)它与鼠的单克隆的anti-PHSA的反应,可受到PHSA和乙型肝炎病毒(HBV)上的聚合人血清白蛋白受体(PHSA-R)的抑制。(3)它可在异种动物体内诱导产生具有anti-PHSA活性的抗-抗独特型抗体(anti-anti-anti-PHSA,Ab_3),而且在收获的Ab_2血清中也查见了Ab_3。本研究不仅表明了针对PHSA的免疫应答中独特型网络调节的客观存在,而且在其抗独特型抗体(anti-Id)中,的确存在具有PHSA内映像的成分。
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| 关 键 词： | 独特型网络 抗独特型抗体 抗聚合人血清白蛋白抗体 抗-抗聚合人血清白蛋白抗体 |
Anti-idiotypic Antibody Specific for Anti-polymeric Human Serum Albumin |
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| Li Mingyuan. Anti-idiotypic Antibody Specific for Anti-polymeric Human Serum Albumin[J]. Immunological Journal, 1989, 0(4) |
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| Authors: | Li Mingyuan |
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| Affiliation: | Li MingyuanDepartment of Microbiology,West China University of Medical Sciences,Chengdu |
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| Abstract: | The anti-idiotypic antibody (anti-Id, Ab2) specific for anti-polymeric human serum albumin (anti-PHSA, Ab1) was generated by immunizing the white rabbits with the same kind rabbits anti-PHSA (Ab1). The obtained anti-Id (anti-anti-PHSA, Ab2) pos-seses the following properties. (1) It reacted not only with rabbit anti-PHSA but also with raurine monoclonal anti-PHSA. (2) It inhibited the binding of PHSA with PHSA receptors (PHSA-R) on hepatitis B virus (HBV).(3) It induced anti-anti (Ab3, or Abl), which had the same specificity as anti-PHSA (Abl), in BALB/c mice. These data indicate that the idiotype (Id) network modulate the immune response to PHSA and that the anti-Id specific for anti-PHSA have the internal image composition. |
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| Keywords: | Idiotype network Anti-Id Anti-PHSA Anti-anti-PHSA |
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