| 植物生物碱抗肿瘤机制 |
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| 引用本文： | 程磊 周秀佳. 植物生物碱抗肿瘤机制[J]. 医学教育探索, 2004, 0(2): 216-221 |
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| 作者姓名： | 程磊 周秀佳 |
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| 作者单位： | 上海中医药大学中药学院 上海201203(程磊)，上海中医药大学中药学院 上海201203(周秀佳) |
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| 摘 要： | 生物碱中的一些种类用于治疗癌症已有相当长的一段时间。回顾了近年来在分子、细胞及生理水平上这些生物碱抗肿瘤的作用机制，包括长春花生物碱类、喜树碱、秋水仙碱、玫瑰树碱等。同时也涉及多药耐药现象。
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| 关 键 词： | 机制 生物碱 抗肿瘤 细胞周期 DNA—拓扑异构酶1 细胞凋亡 多药耐药 |
Review on anticancer mechanism of some plant alkaloids |
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| Abstract. Review on anticancer mechanism of some plant alkaloids[J]. Researches in Medical Education, 2004, 0(2): 216-221 |
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| Authors: | Abstract |
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| Abstract: | s: Alkaloids derived from natural products have long been used as a fertile source of cure for cancer, which is believed to be one of the major causes of death in this century. This article reviews the recent advances of many structures of alkaloids in understanding mechanism of action at the molecular, cellular and physiological levels. The important molecules discussed include vincristine, vinblastine, camptothecin, colchicine, ellipticine etc. The review also discussed the potential use of plant alkaloids on multidrug resistance. |
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| Keywords: | mechanism alkaloids anticancer cell cycle DNA topoisomerase I apoptosis multidrug resistance |
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