The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. I. Taxonomy, fermentation, isolation and physico-chemical properties |
| |
Authors: | Ohtsu Yoshihiro Sasamura Hiromi Tsurumi Yasuhisa Yoshimura Seiji Takase Shigehiro Hashimoto Michizane Shibata Toshihiro Hino Motohiro Fujii Takashi |
| |
Affiliation: | Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. yoshihiro_ohtsu@po.fujisawa.co.jp |
| |
Abstract: | FR225659 and four related compounds are novel gluconeogenesis inhibitors that consist of a novel acyl-group and three abnormal amino acids. They were isolated from the culture broth of Helicomyces sp. No. 19353 and can be purified by absorptive resin and reverse-phase column chromatography. They are potent inhibitors of gluconeogenesis in primary cultured rat hepatocytes and thus may be useful as anti-diabetic agents. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|