复方当归粉针剂对垂体后叶素诱导大鼠心肌缺血的保护作用

摘要目的：观察复方当归粉针剂对垂体后叶素诱导的大鼠缺血心肌的保护作用。方法：将60只大鼠分为空白对照组、模型对照组、复方当归粉针剂低、中、高剂量组，阳性对照组，大鼠腹腔注射垂体后叶素建立急性心肌缺血模型，观察复方当归粉针剂对各组大鼠血清中超氧化物歧化酶（SOD）、丙二醛（MDA）以及心肌梗死面积的影响。结果：复方当归粉针剂可对抗垂体后叶素所致的大鼠急性心肌缺血，增加血清中SOD活力，减少MDA生成，缩小心梗面积。结论：复方当归粉针剂对大鼠心肌缺血有保护作用，其机制可能与抗脂质过氧化有关。

Protection Action of Compound Angelica Injectable Powder on Myocardial Ischemia Induced by Pituitrin in Rats

Objective： To observe the protection action of Compound angelica injectable powder on rat＇ s myocardial ischemia. Method： Sixty cases of rats were divided into normal control group, ischemia model group, compound angelica injectable powder low group, medium group and high group, positive control group, pituitrin（ 20 u·kg^-1） was intraperitoneal injected to established the model of acute myocardial ischemia. The effect of Compound angelica injectable powder on SOD, MDA in blood serum and the infarction myocardiam area were observed. Result： Compound angelica injectable powder could protect the acute myocardial ischemia induced by pituitrin, the activity of SOD in serum was improved, the production of MDA was decreased, and the infarction myocardiam area was deflated. Conclusion： Compound angelica injectable powder has protection action on myocardial ischemia of rats, which mechanism maybe related to the action of anti lipid peroxidetion.