自身配对的锯齿状腺瘤与传统腺瘤临床病理特征的比较

目的探讨锯齿状腺瘤与传统腺瘤的癌变潜能的差异。方法 2007年4月～2009年9月经肠镜检出、并经病理检查证实、同时具有锯齿状腺瘤、管状腺瘤的病例。从腺瘤的临床特征（生长部位、直径大小、蒂部情况及异型增生程度）及免疫组化（β-连环蛋白、P53、Ki67）两个方面,比较两者差异。结果同时具有SA及TA的16例,男性13例,女性3例,年龄43～81岁,平均年龄62.9岁;2种腺瘤的部位分布、异型增生程度及直径大小无显著性差异,无蒂的SA明显多于TA,差异有统计学意义（P〈0.05）;β-连环蛋白、P53、Ki67在2种腺瘤中表达水平无显著差异。结论同1个体的锯齿状腺瘤与传统腺瘤的临床病理特征无显著性差异。

Self-matching Comparison of the Clinical Pathological Features Analysis in Cases with Both Serrated Adenomas & Traditional Adenomas

Objective To analyze the cancer potential differences of serrated adenoma and traditional adenoma.Methods Cases with both SA TA（colonoscopically detected pathologically confirmed from）from April 2007 to September 2009 were selected,the clinical features of adenoma（location,size,pedicle and the degree of dysplasia）as well as immunohistochemical staining（β-catenin protein,P53,Ki67）were analyzed.Results There were 16 cases with both SA and TA,in which 13 were males and 3 females,and the ages were from 43 to 81 yrs with an average of 62.9 years;No significant difference was found in terms of location,diameter and the degree of dysplasia.However,sessile type of adenoma in SA was more than that in TA（P0.05）;No significant difference was noticed in terms of β-catenin protein,P53 and Ki67 expression.Conclusion There was no significant difference was found between the SA and TA in terms of clinical/pathological characteristics.