Binding of neutralizing monoclonal antibodies to empty capsids of poliovirus can be blocked by monospecific antisera to structural polypeptides VP1 and VP2 |
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| Authors: | H. Uhlig Frauke Haardt R. Dernick |
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| Affiliation: | (1) Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Hamburg, Germany;(2) Present address: Physiologisch-chemisches Institut, Universität Hamburg, Martinistrasse 52, D-2000 Hamburg 20, Germany |
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| Abstract: | Summary Binding of two neutralizing monoclonal antibodies (Nt-mAbs) to natural empty capsids (NEC) of poliovirus, type 1, was blocked to the extent of 83 per cent to 98 per cent by monospecific rabbit antisera directed against the structural polypeptides VP1 and VP2. Monospecific antisera against VP3 or VP4, however, did not show this blocking effect. It is therefore assumed that VP1 and VP2 are located close together at the antigenic sites for the two mAbs.With 1 Figure |
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