| 强心益气汤对多柔比星所致急性心衰大鼠心功能的保护作用 |
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| 引用本文： | 胡玉录,张贺龙,吴明华,张伟,张建平,李国明,李乾,王彦田,楚立.强心益气汤对多柔比星所致急性心衰大鼠心功能的保护作用[J].中华中医药杂志,2010(6). |
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| 作者姓名： | 胡玉录 张贺龙 吴明华 张伟 张建平 李国明 李乾 王彦田 楚立 |
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| 作者单位： | 河北医科大学第二医院药剂科;河北省胸科医院内科;河北医科大学基础课教学部药理教研室; |
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| 基金项目： | 河北省科技厅科技攻关课题(No.06276102D-29); 河北省中医药管理局课题(No.2007023)~~ |
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| 摘 要： | 目的:观察强心益气汤对多柔比星致急性心衰大鼠心功能的影响及机制。方法:一次性腹腔注射多柔比星10mg/kg,复制急性心衰大鼠模型。强心益气汤灌胃6d后,观察心室内压变化、血清中超氧化物歧化酶(super oxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)含量的影响以及观察心肌病理形态学的改变。结果:强心益气汤各组均能不同程度改善血流动力学并能明显升高血清SOD、降低MDA含量;HE染色结果显示,强心益气汤各组心肌细胞变性坏死明显减轻。结论:强心益气汤能够明显改善多柔比星心肌毒性导致的急性心衰,该作用可能与调节大鼠体内自由基代谢及增强心脏泵血功能有关。
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| 关 键 词： | 强心益气汤 多柔比星 充血性心力衰竭 血流动力学 |
Protective effects of Qiangxin Yiqi Decoction on heart function of rats with doxorubicin-induced acute heart failure |
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| HU Yu-lu,ZHANG He-long,WU Ming-hua,ZHANG Wei,ZHANG Jian-ping,LI Guo-ming,LI Qian,WANG Yan-tian,CHU Li.Protective effects of Qiangxin Yiqi Decoction on heart function of rats with doxorubicin-induced acute heart failure[J].China Journal of Traditional Chinese Medicine and Pharmacy,2010(6). |
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| Authors: | HU Yu-lu ZHANG He-long WU Ming-hua ZHANG Wei ZHANG Jian-ping LI Guo-ming LI Qian WANG Yan-tian CHU Li |
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| Institution: | HU Yu-lu1,ZHANG He-long2,WU Ming-hua3,ZHANG Wei3,ZHANG Jian-ping3,LI Guo-ming3,LI Qian3,WANG Yan-tian3,CHU Li3(1Department of Pharmacy,the Second Hospital of Hebei Medical University,Shijiazhuang 050011,China,2Department of Internal Medicine,Hebei Chest Hospital,Shijiazhuang 050048,3Department of Pharmacology,Preclinical Medical School of Hebei Medical University,Shijiazhuang 050091,China) |
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| Abstract: | Objective:To observe the protective effects and mechanisms of Qiangxin Yiqi Decoction(QXYQD) on heart function of rats with doxorubicin-induced acute heart failure.Methods:SD rats were randomly divided into 4 groups:normal control (NC) group,model control (MC) group,low dosage of QXYQD (L-QXYQD) group,high dosage of QXYQD (H-QXYQD) group.QXYQD was repeatedly administered at dose of 24,72g/kg,respectively,1 time a day for 6d.On the 7th day,the model control and QXYQD groups were administered with doxorubicin... |
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| Keywords: | Qiangxin Yiqi Decoction Doxorubicin Congestive heart failure Hemodynamics |
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