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| 注射用载胸苷激酶基因质粒PLGA纳米粒的质量研究 | |
| 引用本文： | 何勤,刘戟,徐超群,张志荣. 注射用载胸苷激酶基因质粒PLGA纳米粒的质量研究[J]. 中国医药工业杂志, 2006, 37(10): 682-684 |
| 作者姓名： | 何勤 刘戟 徐超群 张志荣 |
| 作者单位： | 1. 四川大学华西药学院 2. 四川大学基础医学与法医学院,四川,成都,610041 3. 四川省中药研究所,四川,成都,610038 |
| 摘 要： | 制备了注射用载胸苷激酶（TK）基因质粒PLGA纳米粒的冻干剂，并对其形态、粒径、稳定性、体外抗核酸酶和抗超声能力等进行了观察。结果表明，纳米粒可提高TK基因对核酸酶和超声的抵抗能力。 |
| 关 键 词： | 胸苷激酶基因 纳米粒 聚丙交酯乙交酯 |
| 文章编号： | 1001-8255（2006）10-0682-03 |
| 收稿时间： | 2005-12-19 |
| 修稿时间： | 2005-12-19 |
Quality Evaluation of Injectable Thymine Kinase Gene Plasmid PLGA-Nanoparticles |
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| HE Qin,LIU Ji,XU Chao-Qun,ZHANG Zhi-Rong. Quality Evaluation of Injectable Thymine Kinase Gene Plasmid PLGA-Nanoparticles[J]. , 2006, 37(10): 682-684 | |
| Authors: | HE Qin LIU Ji XU Chao-Qun ZHANG Zhi-Rong |
| Affiliation: | 1.Huaxi School of Pharmacy,Sichuan University;2.Huaxi School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041;3.Sichuan Institute of Chinese Materia Medica,Chengdu 610038 |
| Abstract: | The injectable lyophilized nanoparticles loaded with thymine kinase gene was prepared.The morphology,particle,preliminary stability,anti-nuclease ability and anti-ultrasonic radiation of the products were investigated.The results showed that the nanoparticles could enhance the resistance ability of plasmid DNA to nuclease or ultrasound. |
| Keywords: | thymine kinase gene nanoparticle PLGA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |