Human placental growth hormone is increased in maternal serum at 20 weeks of gestation in pregnancies with large-for-gestational-age babies |
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| Authors: | Shutan Liao Mark H Vickers Rennae S Taylor Beatrix Jones Mhoyra Fraser Lesley M E McCowan |
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| Institution: | 1. Liggins Institute, University of Auckland, Auckland, New Zealand,;2. Gravida: National Centre for Growth and Development, Auckland, New Zealand,;3. The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China,;4. Gravida: National Centre for Growth and Development, Auckland, New Zealand,;5. Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand,;6. Institute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand,;7. Department of Physiology, University of Auckland, Auckland, New Zealand, and |
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| Abstract: | To investigate the relationship between maternal serum concentrations of placental growth hormone (GH-V), insulin-like growth factor (IGF)-1 and 2, IGF binding proteins (IGFBP)-1 and 3 and birth weight in appropriate-for-gestational-age (AGA), large-for-gestational-age (LGA) and small-for-gestational-age (SGA) cases in a nested case-control study. Maternal serum samples were selected from the Screening for Pregnancy Endpoints (SCOPE) biobank in Auckland, New Zealand. Serum hormone concentrations were determined by ELISA. We found that maternal serum GH-V concentrations at 20 weeks of gestation in LGA pregnancies were significantly higher than in AGA and SGA pregnancies. Maternal GH-V concentrations were positively correlated to birth weights and customized birth weight centiles, while IGFBP-1 concentrations were inversely related to birth weights and customized birth weight centiles. Our findings suggest that maternal serum GH-V and IGFBP-1 concentrations at 20 weeks' gestation are associated with fetal growth. |
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| Keywords: | Placental growth hormone birth weight pregnancy large-for-gestational-age |
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