血清同型半胱氨酸、维生素B12、叶酸与妊娠期糖尿病的临诊研究

目的]探讨妊娠期糖尿病（gestationaldiabetesmellitus，GDM）患者血清叶酸（folicacid，FA）、维生素（vitamin，Vit）B12和同型半胱氨酸（homocys—teine，Hcy）水平及其与GDM的关系。方法】选择2011年6月至2012年12月我院经口服葡萄糖耐量试验（oralglucosetolerancetest，0GTT）确诊的GDM患者40例及同期健康孕妇40例，采用循环酶法检测Hcy浓度；采用化学发光免疫法检测FA及VitB12水平。【结果】GDM患者血清Hcy、VitB12、FA与正常妊娠组比较，Hcy水平显著升高（P〈0．01），FA和VitB，2显著降低（P〈0．01）。GDM患者血清Hcy水平与VitB12、FA水平呈负相关关系。【结论】GDM孕晚期患者出现高Hcy血症，缺乏FA及VitB12，妊高症患者应加强VitB12和FA的摄入及定期监测，从而降低Hcy水平，减轻其对GDM孕妇大血管和微血管的损害以及对胎儿的不良影响。

Clinical Study on Serum Homocysteine,Bn Folic Acid and Gestationai Diabetes Mellitus

Objective] To explore the levels of fotic acid（FA）, vitamin（Vit） B12 and homocysteine（Hcy） of gestational diabetes meUitus（GDM） patients and the relation among them. Method] Select 40 GDM cases from our hospital diagnosed with oral glucose tolerance test（0GTT） and 40 healthy pregnant women in the same period, take circulation enzymic method to test Hey concentration, and take chemiluminescence to measure FA and VitB12. Result] GDM patients＇Hey level is in negative relation with VitBt2 and FA levels. Comparing GDM patients＇ serum Hcy,VitB12 and FA with normal pregnant group, I-Icy level is raised much（P〈0.01 ）, FA and VitB12 are reduced markedly（P〈0.01 ）. In later period of GDM pregnancy, they have high Hey, lack of FA and VitB12; the pregnancy hypertension shall strengthen the intake of VitB12 and FA, as well as have periodical supervision, to reduce Hey level and decrease the side effects on fetus and injury to pregnant women＇s great vessels and micro-vessels.