干细胞用于心脏再生的研究进展

[目的]主要综述心肌细胞的再生潜力及所涉及的可能机制的研究成果。[方法]通过心脏干细胞CSCs，造血干细胞HSCs，心肌细胞去分化与心肌再生的关系及其可能涉及的机制等各方面来综述心脏再生能力。[结果]c—kit阳性的CSCs自我更新，在试管内和活体内均可产生分化细胞；在生理状态下及损伤后c—kit阳性的CSCs都具有克隆性和多向分化的潜能。造血干细胞可以转分化并生成心肌细胞和冠状血管，用于人类的细胞疗法。去分化细胞维持和改善受损心脏的心室功能的作用十分有限。[结论]心脏干细胞CSCs和造血干细胞HSCs在扭转慢性缺血性和非缺血性心脏衰竭中发挥重要的作用。

Review on Stem Ceils Used on Heart Regeneration

[Objective] This article mainly discussed the potential of myocardial cell regeneration and the possible mechanisms involved. [Method] To study the mechanism of cardiac regeneration ability HSCs, this review studyed the relationship of the differentiation of cardiac stem cells, hematopoietic stem cells, myocardial ceils and myocardial regeneration and the possible mechanisms involved. [Result] Self-renewing, differentiation both in vitro and in vivo of the c-kit positive CSCs had been seen. No matter in physiological condition or after damage, the c-kit positive CSCs had clonality and the potential of multi-directional differentiation. Hematopoietic stem cells can generate cardiomyocytes and coronary blood vessels for human cell therapy. The ability of dedifferentiation cells to maintain and improve the ventricnlar function of a damaged heart is very limited. [Conclusion] CSCs and HSCs play an important role in reversing chronic ischemic and non-ischemic heart failure.