| 吡喹酮中间体N-苯乙基氯乙酰胺的合成工艺改进 |
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| 引用本文： | 王凤军,马淑涛,翟吉胜. 吡喹酮中间体N-苯乙基氯乙酰胺的合成工艺改进[J]. 齐鲁药事, 2013, 0(12): 740-741 |
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| 作者姓名： | 王凤军 马淑涛 翟吉胜 |
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| 作者单位： | [1]山东大学药学院,山东济南250012 [2]山东新华制药股份有限公司山东淄博255005,山东济南250012 |
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| 摘 要： | 目的改进吡喹酮中间体N-苯乙基氯乙酰胺的合成工艺,减少二次和多次缩合副产物。方法改进加料方式,将滴加氯乙酰氯改进为滴加β-苯乙胺。结果及结论副产物大幅降低,目标产物含量98.67%,收率94.01%。
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| 关 键 词： | N-苯乙基氯乙酰胺 吡喹酮 中间体 合成 |
Improvement on synthesis process of the intermediate of praziquantel 2-chloro-N-phenethylacetamide |
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| WANG Feng-jun,MA Shu-tao,ZHAI Ji-sheng. Improvement on synthesis process of the intermediate of praziquantel 2-chloro-N-phenethylacetamide[J]. qilu pharmaceutical affairs, 2013, 0(12): 740-741 |
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| Authors: | WANG Feng-jun MA Shu-tao ZHAI Ji-sheng |
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| Affiliation: | 1. School of Pharmaceutical Science, Shandong University, Jinan 250012, China ;2. Shandong Xinhua Pharmaceutical Co. , Ltd. , Zibo 255005, China ) |
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| Abstract: | Objective To improve the synthetic method of intermediate of praziquantel. Methods Change the feeding material sequence. Results and Conclusion The new synthetic method can steady the yield at 94% ,which was 13% high- er than reported in the literature. |
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| Keywords: | 2 - Chloro - N - phenethylacetamide Praziquantel Intermediate Preparation |
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