Establishment of a therapeutic model for retroviral infection using the genetic resistance mechanism of the host |
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| Authors: | Masanobu Kitagawa Shiro Aizawa Hidetoshi Ikeda Katsuiku Hirokawa |
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| Affiliation: | Department of Pathology and Immunology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo;Division of Physiology and Pathology, National Institute of Radiological Sciences, Angina, Chiba;Laboratory of Immunogenetics, National Institute of Animal Health, Tsukuba, Ibaraki, Japan |
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| Abstract: | Resistance to retroviral infection is often regulated by multiple genes that control different aspects of the host-virus interaction. Genetically distinct inbred strains of mice differ in their susceptibility to retrovirus and have allowed the identification of several host-resistant loci that regulate the host defense mechanism to retroviral Infection. Using the murine retrovirus infection system, a therapeutic model has been developed of retrovirus Infection In association with the resistant mechanism of host genes. The most effective result achieved with the model was when using bone marrow transplantation of retrovirus-reslstant cells with receptor interference function, which was genetlcally defined by the Fv-4 resistant gene. The possible appllcatlon of these findings to the gene therapy of retrovirus-induced disease of humans Is discussed. |
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| Keywords: | bone marrow transplantation Fv-4 gene therapy receptor interference retrovirus |
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