| E-cd/γ-cat复合体在膀胱癌中的表达及临床意义 |
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| 引用本文： | 周岩,陶秀林,李先承,宋希双. E-cd/γ-cat复合体在膀胱癌中的表达及临床意义[J]. 肿瘤防治研究, 2004, 31(7): 398-399,405 |
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| 作者姓名： | 周岩 陶秀林 李先承 宋希双 |
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| 作者单位： | 1. 318000,浙江台州市立医院泌尿外科
2. 大连医科大学附属第一医院泌尿外科 |
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| 摘 要： | 目的 探讨上皮钙黏蛋白 /γ -连接素 (E cd/γ cat)复合体在膀胱癌中的表达及临床意义。方法应用免疫组织化学法 (S P法 )检测 72例膀胱癌和 5例正常膀胱黏膜石蜡包埋标本中E cd/γ cat复合体的表达情况。结果 所有 5例正常膀胱黏膜E cd/γ cat复合体正常表达。E cd、γ cat异常表达率分别为 4 1/ 72 (5 6 .9% )、31/ 72 (4 3.1% )。E cd和γ cat表达具有显著相关性 (P <0 .0 1)。E cd/γ cat复合体异常表达率与膀胱癌的病理分级和临床分期密切相关 (P <0 .0 5 )。γ cat异常表达与膀胱癌的预后密切相关 (P <0 .0 1)。结论 E cd/γ cat复合体的异常表达与膀胱癌的分化和侵袭程度密切相关。γ cat是判断膀胱癌预后的有价值指标
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| 关 键 词： | 上皮钙黏蛋白 连接素 膀胱癌 预后指标 |
| 文章编号： | 1000-8578(2004)07-0398-02 |
| 收稿时间： | 2003-06-26 |
| 修稿时间： | 2003-10-27 |
E-cadherin/γ-catenin Complex Expression in Human Bladder Carcinoma and Its Clinical Significance |
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| ZHOU Yan ,TAO Xiu lin ,LI Xian cheng ,SONG Xi shuang. E-cadherin/γ-catenin Complex Expression in Human Bladder Carcinoma and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2004, 31(7): 398-399,405 |
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| Authors: | ZHOU Yan TAO Xiu lin LI Xian cheng SONG Xi shuang |
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| Affiliation: | ZHOU Yan 1,TAO Xiu lin 1,LI Xian cheng 2,SONG Xi shuang 2 1.Department of Urology,Taizhou Municipal Hospital,Taizhou 318000,China,2.Department of Urology,First Affiliated Hospital of Dalian Medical University |
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| Abstract: | Objective To elucidate the expression of E cadherin/γ catenin(E cd/γ cat)complex and its clinical significance in human bladder carcinoma.Methods The immunohistochemical staining with streptavidin peroxidase conjugated method (S P) was used to examine the expression of E cd/γ cat complex in 72 cases of human bladder carcinoma and 5 cases of normal bladder mucosa.Results E cd/γ cat complex was expressed in a normal membranous pattern in all normal bladder mucosa specimens. The abnormal expression... |
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| Keywords: | E cadherin Catenin Bladder carcinomas Prognostic marker |
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