新型可降解涂层药物支架治疗澳门华裔人群冠心病的临床应用和效果分析

目的探讨Nobori支架治疗澳门华裔人群冠心病的有效性和安全性。方法将50例冠心病患者随机分成Nobori组（n=20）和Xience V组（n=30）,分别植入上述支架,术后随访观察支架内血栓形成、心源性死亡、心肌梗死、需冠状动脉搭桥、靶病变血运重建（TLR）、靶血管血运重建（TVR）、靶病变失败（TLF）、主要不良心血管事件（MACE）等指标。结果在随访2年支架内血栓形成发生率方面,早期、晚期两组相同,超晚期血栓形成发生率Nobori组稍高（5.0%vs.3.3%,P〉0.05）,但差异无统计学意义。在随访1年的主要终点事件发生率方面,Xience V组的MACE稍高（3.3%vs.0.0%,P〉0.05）,但差异无统计学意义。在随访2年的主要终点事件发生率方面,Xience V组的MACE稍高（6.7%vs.5.0%,P〉0.05）,但差异也无统计学意义。结论 Nobori支架治疗华裔人群有一定的安全性和有效性,其疗效与Xience V支架疗效相当,值得临床推广。

Clinical application and effect analysis of novel biodegradable coated stent in the treatment of Macau Chinese patients with coronary heart disease

Objective To investigate the safety and efiScaey of Nobori steut in the treatment of Maeau Chinese patients with coronary heart disease. Methods 50 Chinese CHD patients were randomly assigned into Nobori group（n =20）and Xience V group（ n = 30）and were implanted with these stents above respectively. Steut thrombosis, cardiogenic death, myocardial infarction, coronary artery bypass graft surgery （CABG）, target lesion revascularization（ TLR ）, target vessel revascularization （TVR）, target lesion failure （TLF）and major adverse cardiovascular events（MACE） were observed in the follow-up. Results In the follow-up of 2 years,the rate of early and late stent thrombosis were the same in the 2 groups. The rate of very late stent thrombosis was a little higher in Nobori group（5.0% vs. 3. 3% ,P 〉0. 05）. In the follow-up of 1 year for primary end points,the rate of MACE was a little higher in Xience V group, but no significant difference （ 3. 3% vs. 0. 0%, P 〉 0. 05 ）. In the follow-up of 2 years,the rate of MACE was a little higher in Xience V group,but still no significant difference（6.7% vs. 5.0%, P 〉 0. 05 ）. Conclusions Implanting Nobori stem is a safe and effect way to treat Chinese. It is not inferior to Xience V steut and deserves promotion in practice.