| 眼睑恶性肿瘤中P16蛋白的表达 |
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| 引用本文： | 刘夫玲,牛膺筠,王红云,林红. 眼睑恶性肿瘤中P16蛋白的表达[J]. 青岛大学医学院学报, 2000, 36(1): 17-19 |
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| 作者姓名： | 刘夫玲 牛膺筠 王红云 林红 |
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| 作者单位： | 1. 青岛市第八人民医院眼科,青岛,266100
2. 青岛大学医学院附属医院眼科 |
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| 摘 要： | ①目的 探讨Ｐ１６蛋白在眼睑恶性肿瘤中的表达情况及其与眼睑恶性肿瘤发生、发展的关系。②方法 应用免疫组化ＳＡＢＣ法检测９６例常见眼睑恶性肿瘤的Ｐ１６蛋白。③结果 眼睑恶性肿瘤Ｐ１６蛋白阳性者均为细胞核染色，其中２８例基底细胞癌（ＢＣＣ），１８例鳞状细胞癌（ＳＣＣ），１３例睑板腺癌Ｐ１６蛋白呈阳性表达，阳性率分别为７０．００％，５４．５５％，５６．５２％，随肿瘤分化程度的降低，Ｐ１６蛋白阳性表达，阳
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| 关 键 词： | 眼睑肿瘤 P16蛋白 免疫组织化学 基因表达 |
| 文章编号： | 1001-4047(2000)01-0017-03 |
| 修稿时间： | 1999-10-20 |
A STUDY OF THE EXPRESSION OF P16 PROTEIN IN CUTANEOUS EYELID TUMORS |
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| LIU Fuling,NIU Yingjun,WANG Hongyun,et al Deparment of Ophthalmology,No. People's Hospital of Qingdao,Qingdao [. A STUDY OF THE EXPRESSION OF P16 PROTEIN IN CUTANEOUS EYELID TUMORS[J]. Acta Academiae Medicinae Qingdao Universitatis, 2000, 36(1): 17-19 |
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| Authors: | LIU Fuling NIU Yingjun WANG Hongyun et al Deparment of Ophthalmology No. People's Hospital of Qingdao Qingdao [ |
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| Affiliation: | LIU Fuling,NIU Yingjun,WANG Hongyun,et al Deparment of Ophthalmology,No.8 People's Hospital of Qingdao,Qingdao 266100 [ |
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| Abstract: | Objective To investigate the expression of P16 in malignant eyelid tumors and to determine the relationship between P16 protein and the occurrence and development of malignant eyelid tumors. Methods SABC immunohistochemistry method was used to study P16 protein in 96 malignant eyelid tumors. Results All positive cells for P16 protein were nuclear stained. The positive expression of P16 protein was detected in 28 cases of basal cell carcinoma (BCC),18 cases of squamous cell carcinoma (SCC),13 cases of subaceous carcinoma. The P16 positive rate decreased with the decreasing degree of histological differentiation. Conclusion The expression of P16 protein is related with the occurrence and degree of differentiation of malignant eyelid tumors. [ |
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| Keywords: | eyelid neoplasms protein P16 immunohistochemistry |
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