2型糖尿病患者血清超敏C-反应蛋白检测的临床应用

目的 探讨2型糖尿病患者血清超敏C-反应蛋白（hs-CRP）水平及与糖化血红蛋白（GSB）、总胆固醇（TC）、总胆固醇（TC）／高密度脂蛋白胆固醇（HDL-C）的关系。方法 采用德国BN-Prospec特定蛋白仪、伯乐DiaSTAT糖化血红蛋白仪、日立OLYMPUS2700生化分析仪对56例2型糖尿病患者及40例健康对照的hs—CRP、GSB、TC、TC／HDL—C进行测定。56例2型糖尿病患者被分成为两组：A组无临床并发症（包括视网膜病变、肾病及神经障碍）；B组至少有一种临床并发症。结果 56例2型糖尿病患者hs—CRP比40例健康对照明显升高（P〈0．001），在2型糖尿病组中B组hs—CRP比A组明显升高（P〈0．001），且与GSB、TC、TC／HDL—C正相关。结论 hs—CRP可作为2型糖尿病并发症出现的风险预测指标。

Clinical application of serum high-sensitivC-Reactive Proteins(hs-CRP)in type 2 diabetes

Objective To investigate the levels of serum high-sensitive C-Reactive Proteins（hs-CRP）in type 2 diabetes（T2DM）,and the relationship of high-sensitivity C-reactive protein （hsCRP）and glycosylated hemoglobin （GSB） ,total choleslerol（ TC ） , ratio of total choleslerol（ TC ）/ high density lipoprotein choleslerol（ HDL- C,TC/HDL-C）. Methods Hs-CRP and GSB,TC,TC/HDL-C in 56 patients of T2DM and 40 health controls were measured by BN-Prospec,DiaSTAT, OLYMPUS2700. 56 patients in T2DM were divided into to 2 groups：A group had no complication （retinopathy,nephrosis and neurological disorder） ;B group had at least a clinical complication. Results The serum hs-CRP in the 56 patients of T2DM was higher than those of 40 health controls（ P 〈0. 001 ） , B group was higher than A group（ P 〈 0. 001 ）. Hs-CRP is positively correlated with GS,TC,TC/HDL- C. Conclusion Hs-CRP is regarded as a marker to estimate the risk of complication of T2DM.