| 双酚A对断乳期SD大鼠F_1雄性子代性激素水平影响 |
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| 引用本文： | 吕波,詹平,姚永革,夏茵茵,黄湫淇.双酚A对断乳期SD大鼠F_1雄性子代性激素水平影响[J].现代预防医学,2010,37(7). |
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| 作者姓名： | 吕波 詹平 姚永革 夏茵茵 黄湫淇 |
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| 作者单位： | 重庆医科大学公共卫生学院,重庆,400016 |
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| 基金项目： | 重庆医科大学创新基金 |
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| 摘 要： | 目的]探讨双酚A(BisphenolA,BPA)对断乳期SD大鼠F1雄性子代性激素水平的影响。方法]从孕0d对母鼠染毒50mg/kg、100mg/kg、200mg/kgBPA至断乳期停止染毒,观察F1雄性子代性激素水平的变化。结果]F0亲代母鼠经BPA持续染毒后,断乳期末200mg/kg BPA实验组血清催乳素(PRL)水平高于对照组,差异有统计学意义(P﹤0.05);100mg/kg、200mg/kg组E2水平高于对照组,差异有统计学意义(P﹤0.05)。20日龄F1雄性子代200mg/kgBPA组血清卵泡刺激素(FSH)浓度较对照组降低,差异有统计学意义(P﹤0.05);50mg/kg,100mg/kg,200mg/kg BPA组血清雌二醇(E2)浓度显著高于对照组,差异有统计学意义(P﹤0.05);各BPA实验组血清睾酮(T)浓度显著低于对照组,差异有统计学意义(P﹤0.05);20日龄F1雄性子代100mg/kg、200mg/kg组睾丸脏器系数较对照组明显减小,有统计学意义(P﹤0.05)。结论]BPA可导致F1雄性子代性激素水平的变化,具有典型的雌激素效应。
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| 关 键 词： | 双酚A 断乳期SD大鼠F1子代雄性 性激素水平 |
THE EFFECTS OF BISPHENOL A ON SEX HORMONES LEVELS OF F_1 MALE RATS DURING WEANING PERIOD |
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| LV Bo,ZHAN Ping,YAO Yong-Ge,et al..THE EFFECTS OF BISPHENOL A ON SEX HORMONES LEVELS OF F_1 MALE RATS DURING WEANING PERIOD[J].Modern Preventive Medicine,2010,37(7). |
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| Authors: | LV Bo ZHAN Ping YAO Yong-Ge |
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| Institution: | LV Bo,ZHAN Ping,YAO Yong-Ge,et al.(School of Public Health,Chongqing University of Medical Science,Chongqing 400016,China) |
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| Abstract: | Objective] To study the effect of BPA on sex hormone of F1 generation male rats during weaning period by tests.Methods] The female rats were exposed to bisphenol-A from 0 day after preganacy to the weaning period at doses of 50,100 and 200 mg / kg,respectively.The sex hormones levels of F1 generation male rats were determined.Results] The study showed that after continuously treated with bisphenol-A,F0 generation female rats fed with 200 mg / kg bisphenol-A had a significantly higher serum PRL level at t... |
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| Keywords: | Bisphenol-A F1 male rats during weaning period Sex hormone level |
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