| 缺氧缺血性脑病新生儿血浆一氧化氮与氧自由基的变化及意义 |
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| 引用本文： | 刘立新,黄凤仙.缺氧缺血性脑病新生儿血浆一氧化氮与氧自由基的变化及意义[J].山西医药杂志,1999,28(4):275-276. |
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| 作者姓名： | 刘立新 黄凤仙 |
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| 作者单位： | 山西医科大学第一医院，阳泉市第一人民医院 |
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| 摘 要： | 目的：探讨一氧化氮（ＮＯ）及氧自由基（ＯＦＲ）在新生儿缺氧缺血性脑病（ＨＩＥ）中的作用及意义。方法：取正常及ＨＩＥ急性期新生儿的静脉血制备成血浆，采用硝酸还原酶法测定ＮＯ的含量，用化学比色法测定ＭＤＡ的含量及ＳＯＤ的活力，用ＥＬＩＳＡ法测定ＮＳＥ水平。结果：ＨＩＥ急性期新生儿血浆ＮＯ、ＭＤＡ及ＮＳＥ水平较正常对照组新生儿均明显增高（均Ｐ＜０．０１）；而ＳＯＤ活力则明显降低（Ｐ＜０．０１）。结论：ＮＯ和ＯＦＲ与新生儿ＨＩＥ的发病机制有关。
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| 关 键 词： | 缺氧缺血性脑病 新生儿 一氧化氮 氧自由基 |
CHANGES AND EFFECTS OF PLASMA NITROUS OXIDE AND OXYGEN FREE RADICALS IN NEONATE WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY |
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| Liu Lixin,Yuan Pingfei,Wang Jingmin,Jin Ying,Hao Yizhong,Huang Fengxian,Liu Baofeng.CHANGES AND EFFECTS OF PLASMA NITROUS OXIDE AND OXYGEN FREE RADICALS IN NEONATE WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY[J].Shanxi Medical Journal,1999,28(4):275-276. |
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| Authors: | Liu Lixin Yuan Pingfei Wang Jingmin Jin Ying Hao Yizhong Huang Fengxian Liu Baofeng |
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| Abstract: | Objective:To study the effects of NO and OFR(oxygen free radical) in the neonates with hypoxic ischemic encephalopathy (HIE).Methods:Two groups of neonates were prepared, namely:① normally control group; ② HIE acute group.NO,MDA(malonyldialdehyde),SOD(superoxide dismutase) and NSE(neuron specific enolase) in the plasma were measured.Results:Compared with control group,the plasma NO,MDA and NSE levels increased significantly (P<0.01),SOD activity decreased significantly (P<0.01) in HIE acute group.Conclusion:NO and OFR are related to pathogenesis of HIE in the neonates. |
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| Keywords: | HIE neonate NO OFR |
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