洛沙坦抗高血压及左室肥厚的疗效观察

目的 :观察血管紧张素 受体拮抗剂—洛沙坦的降压效果及对高血压病合并左室肥厚的影响。方法 :4 6例合并左室肥厚的 期高血压病患者服用洛沙坦 5 0 mg/ d,观察其血压的变化及治疗前和 6个月后左室质量 (L VM)。结果 :用洛沙坦后 4 d～ 6d血压开始下降 ,2周血压趋向正常 ,4周血压继续缓慢下降 ,6周时达到最大降压效果。 L VM在 12周时无明显变化。 2 4周表现轻度 L VM减少。结论 :洛沙坦是抗高血压的一个有效治疗药物 ,对左心室肥厚有轻度逆转作用

THERAPEUTIC OBSERVATIONS OF LOSARTAN AGAINST HYPERTENSION AND LEFT VENTRICULAR HYPERTROPHY

Objective:To observe the antihypertensive efficacy and the influence on left ventricular hypertrophy of losartan,a angiotensin Ⅱ( AT1 subtype) receptor antagonist.Methods:Losartan 50 mg/d was given in 46 patients with hypertension (stage Ⅱ).The blood pressure and left ventricular mass(LVM) were observed before and after therapy with losartan.Results:The blood pressure started to drop after a losartan therapy of 4～6 days.It tended to be normal in 2 weeks,a slow drop continued in 4 weeks,reaching the top hypotensive efficacy in 6 weeks.LVM was not changed significantly in 12 weeks,but was slightly decreased after a 24 week losartan therapy.Conclusion:Losartan is an effective antihypertensive drug with a slight reversal action to LVM.