| 基于SVM方法构建细菌sRNA靶标预测模型 |
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| 引用本文： | 赵雅琳,李华,侯妍妍,查磊,曹源,王立贵,应晓敏,李伍举. 基于SVM方法构建细菌sRNA靶标预测模型[J]. 军事医学科学院院刊, 2008, 32(4) |
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| 作者姓名： | 赵雅琳 李华 侯妍妍 查磊 曹源 王立贵 应晓敏 李伍举 |
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| 作者单位： | 军事医学科学院基础医学研究所计算生物学中心,北京,100850 |
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| 基金项目： | 国家高技术研究发展计划(863计划)，国家自然科学基金 |
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| 摘 要： | 目的:为实验方法鉴定细菌sRNA靶标和研究sRNA功能提供生物信息学支持.方法:首先以实验证实的132个sRNA与靶标相互作用数据为训练集,其中包含46个阳性数据和86个阴性数据;其次,以实验证实的22个阳性数据和随机生成的1 700个阴性数据为测试集;最后以RNA二级结构谱等特征为变量,运用支持向量机(SVM)方法构建sRNA靶标预测数学模型.结果和结论:构建的模型对训练集的敏感性和特异性均为100%,对测试集的敏感性和特异性分别为72.73%和80.65%.所构建的数学模型为实验发现sRNA靶标提供了生物信息学支持.
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| 关 键 词： | 靶标 预测 机器学习 |
Construction of a model for prediction of bacterial sRNA targets using support vector machines |
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| ZHAO Ya-Lin,LI Hua,HOU Yan-Yan,ZHA Lei,CAO Yuan,WANG Li-Gui,YING Xiao-Min,LI Wu-Ju. Construction of a model for prediction of bacterial sRNA targets using support vector machines[J]. Bulletin of the Academy of Military Medical Sciences, 2008, 32(4) |
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| Authors: | ZHAO Ya-Lin LI Hua HOU Yan-Yan ZHA Lei CAO Yuan WANG Li-Gui YING Xiao-Min LI Wu-Ju |
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| Affiliation: | ZHAO Ya-Lin,LI Hua,HOU Yan-Yan,ZHA Lei,CAO Yuan,WANG Li-Gui,YING Xiao-Min*,LI Wu-Ju*(Center of Computational Biology,Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China) |
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| Abstract: | Objective: To provide bioinformatics support for experimental identification of bacterial sRNA targets and for the study of sRNA functions.Methods: To construct a model for prediction of bacterial sRNA targets,132 sRNA-mRNA interactions verified by experiments were collected first as the training dataset,which contained 46 positive samples and 86 negative samples.Then,22 sRNA-mRNA interactions verified by experiments as the positive test dataset and 1700 randomly-generated sRNA-mRNA interactions as the nega... |
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| Keywords: | sRNA SVM |
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