The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon. |
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| Authors: | Y C Wu C Y Duh F R Chang G Y Chang S K Wang J J Chang D R McPhail A T McPhail K H Lee |
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| Affiliation: | School of Pharmacy, Department of Microbiology, Kaohsiung Medical College, Taiwan, Republic of China. |
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| Abstract: | The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells. |
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