葡萄糖对罗哌卡因蛛网膜下腔阻滞的影响

目的观察100 g.L-1葡萄糖对罗哌卡因蛛网膜下腔阻滞时感觉、运动神经阻滞的影响。方法随机选取择期行下腹部及以下手术的患者24例,ASA分级Ⅰ~Ⅱ级,随机分为对照组和观察组。腰硬联合麻醉下,蛛网膜下腔给药。对照组蛛网膜下腔朝头侧注入7.5 g.L-1罗哌卡因1.33 mL+9 g.L-1NaC l 0.67 mL,观察组蛛网膜下腔朝头侧注入7.5 g.L-1罗哌卡因1.33 mL+100 g.L-1葡萄糖。观察比较2组的感觉阻滞起效时间、感觉阻滞持续时间、运动阻滞起效时间、运动阻滞持续时间、最高感觉阻滞平面、最高感觉阻滞时间、最大运动阻滞程度、最大运动阻滞时间。结果观察组感觉阻滞起效时间、感觉阻滞持续时间、运动阻滞起效时间、运动阻滞持续时间以及最大运动阻滞时间均明显短于对照组(P<0.05),最高感觉阻滞平面、最大运动阻滞程度高于对照组(P<0.05),最高感觉阻滞时间2组间无显著差异(P>0.05)。结论罗哌卡因蛛网膜下腔阻滞时,加入100 g.L-1葡萄糖可明显缩短感觉、运动阻滞的起效时间和持续时间,增加感觉阻滞的平面及运动阻滞的程度。

Effects of glucose on subarachnoid block with ropivacaine

Objective To investigate the effects of 100 g · L^-1 glucose on sensory nerve and motor nerve blocking of subarachnoid block with ropivacaine. Methods Twenty-four patients whose grade of ASA were Ⅰ - Ⅱ underwent elective underbelly and the following operation were randomly divided into control group and observation group（ twelve patients in each group） , using combined spinal-epidural anaesthesia,and the medicine were given through subarachnoid Space. The control group were given 7. 5 g · L^-1 ropivacaine 1.33 mL and 9 g · L^-1 NaCl 0.67 mL,the observation group were given 7.5 g · L^-1 ropivacaine 1.33 mL and 100 g · L^-1 glucose 0.67mL. The effect time and duration of feeling block,the effect time and duration of movement block, the highest plane and time of feeling block, the largest degree and the largest time of movement block were compared between two groups. Results In observation group, the effect time and duration of feeling block, the effect time and duration of movement block and the largest time of movement block were obviously lower than in control group（ P 〈 0.05 ）, but the highest plane of feeling block and the largest degree of movement block were higher than in control group （P 〈 0.05 ）. There was no difference in the highest time of feeling block between two groups（ P 〉 0.05 ）. Conclusion Addition of 100 g · L^-1 glucose to ropivacaine in spinal anaesthesia can shorten the onsets and durations of sensory and motor block and increase the degree of sensory and motor block.