高脂对家兔免疫功能的影响

目的探讨高脂喂养对家兔血脂水平及动脉粥样硬化的影响。方法将23只家兔随机分为二组:A组为高脂喂养组(n=20),B组为正常饲料喂养组(n=3);为对照组。分别于高脂喂养前、喂养后2w、4w、8w和12w取家兔耳缘静脉取血各1次,行血清总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白测定。结果A组高脂喂养2w后血清总胆固醇、甘油三酯、低密度脂蛋白水平较高脂喂养前及对照组均明显升高(P0.01)。而4w后高密度脂蛋白也明显升高(P0.01)。结论家兔血脂水平在高脂喂养2-4w即达峰值,并开始下降,而其促动脉粥样硬化作用将延续。

Effect of High-Cholesterol-Diet on the Rabbit's Blood Fat Level

Objective To study the effect of High - Cholesterol - Diet on the rabbit＇s blood fat level and its arth-erosclerosis. Method 23 rabbits were random divided into two groups： A group was High - Cholesterol - Diet group, B group was control group. Each rabbit was examined its blood fat level （TC, TG, HDL - C, LDL - C） before and 2w, 4w, 8w, 12w after High - Cholesterol - Diet. Results Rabbits＇TC, TG, LDL - C level 2w after High - Cholesterol - Diet of A group was significant higher than before and after that of the control group （ P 〈 0：01 ） . Rabbits＇HDL - C level was significant higher After 4w. （ P 〈 0. 01 ） . Conclusions The blood fat level of rabbits is peeking at 2 to 4 weeks by High - Cholesterol - Diet, and breaks down gradually. But its effect to deteriorate arthemsclerosis win last.