| 干扰素-tau微囊的制备工艺优化 |
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| 引用本文： | 付加雷,宋长征,张更林. 干扰素-tau微囊的制备工艺优化[J]. 中国生化药物杂志, 2007, 28(6): 378-381 |
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| 作者姓名： | 付加雷 宋长征 张更林 |
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| 作者单位： | 山东省医学科学院山东省医药生物技术研究中心 卫生部生物技术药物重点实验室,山东济南,250062 |
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| 摘 要： | 目的用壳聚糖和海藻酸钠为原料,制备干扰素-tau微囊。方法采用凝聚法制备了干扰素-tau壳聚糖-海藻酸钠微囊,以包封率、微囊强度为指标,设立总的评估指数,用L9(34)表进行正交实验优化制备工艺。结果最终的优化方案为:2.0%海藻酸钠、0.4%壳聚糖、0.3%干扰素-tau以及1.0%氯化钙溶液。结论该工艺简便、稳定,壳聚糖-海藻酸钠微囊有望用作干扰素-tau或其它蛋白质药物的口服制剂技术。
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| 关 键 词： | 干扰素-tau 壳聚糖 海藻酸钠 包封率 微囊 |
| 文章编号： | 1005-1678(2007)06-0378-04 |
| 修稿时间： | 2007-02-12 |
Optimization of the preparation of interferon tau chitosan-alginate microcapsules |
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| FU Jia-lei,SONG Chang-zheng,ZHANG Geng-lin. Optimization of the preparation of interferon tau chitosan-alginate microcapsules[J]. Chinese Journal of Biochemical Pharmaceutics, 2007, 28(6): 378-381 |
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| Authors: | FU Jia-lei SONG Chang-zheng ZHANG Geng-lin |
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| Abstract: | Purpose The microcapsules were prepared by using chitosan and alginate as raw materials,and the controlled-release microcapsules of interferon tau were hoped to develop an oral interferon preparation.Methods Interferon tau chitosan-alginate microcapsules were prepared by coacervation technology.Four factors and three levels for each factor were selected and arranged in an L9(34) orthogonal experimental table.The evaluating indicator(EI%),calculated according to drug encapsulated efficiency(EE%) and strength of microcapsules(MS%),was introduced as a total index for the microcapsules formulation.Results The best program is:2.0% sodium alginate,0.4% chitosan,0.3% IFN-tau and 1.0% CaCl2.Conclusion The preparation procedure is good,simple and reproducible.Chitosan-alginate microcapsules have the potential to be used in oral administration technology of interferon tau and the other protein medicines. |
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| Keywords: | interferon tau chitosan sodium alginate encapsulation rate microcapsules |
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