| MAGE-3蛋白在非小细胞肺癌中的表达 |
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| 引用本文： | 黎涛,马春山,李川,孙强,王云.MAGE-3蛋白在非小细胞肺癌中的表达[J].实用医药杂志(山东),2007,24(10):1229-1231. |
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| 作者姓名： | 黎涛 马春山 李川 孙强 王云 |
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| 作者单位： | 401医院心胸外科,山东青岛266071 |
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| 摘 要： | 目的检测MAGE-3蛋白在非小细胞肺癌(NSCLC)中的表达,为该蛋白作为疫苗来源对NSCLC患者进行免疫治疗提供依据。方法采用流式细胞术(FCM)对MAGE-3蛋白在3种人肺癌细胞系和56例NSCLC标本及相邻正常肺组织标本中的表达情况进行比较。结果3种人肺癌细胞系均表达MAGE-3蛋白;56例NSCLC标本中,26例表达MAGE-3蛋白,其中鳞状细胞癌的表达率明显高于腺癌的表达率(P<0.01),而相邻正常肺组织均不表达该蛋白。结论MAGE-3蛋白在NSCLC中呈高频率表达,提示该蛋白是对NSCLC患者进行免疫治疗的适宜疫苗来源。
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| 关 键 词： | 肺肿瘤 MAGE-3蛋白 免疫治疗 流式细胞术 |
| 收稿时间： | 2007-05-08 |
| 修稿时间： | 2007年5月8日 |
Expression of MAGE-3 protein in non-small cell lung cancer |
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| LI Tao, MA CHun-shan, LI CHuan,et al..Expression of MAGE-3 protein in non-small cell lung cancer[J].Practical Journal of Medicine & Pharmacy,2007,24(10):1229-1231. |
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| Authors: | LI Tao MA CHun-shan LI CHuan |
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| Institution: | Department of Cardiac-thoracic Surgery, No. 401 Hospital, Qingdao 266071, China |
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| Abstract: | Objective To determine the expression of MAGE-3 protein in non-small cell lung cancer(NSCLC)and to present the evidence of using this protein as the vaccine for immunotherapy of NSCLC patients.Methods The expression of MAGE-3 protein in 3 human lung cancer cell lines and 56 NSCLC samples together with the adjacent normal lung samples was detected by flow cytometry(FCM).Results All 3 human lung cancer cell lines expressed MAGE-3 protein;of the 56 NSCLC samples,26 expressed MAGE-3 protein,and the expression rate in squamous cell carcinoma was higher than in adenocarcinoma,whereas none of the adjacent normal lung samples expressed MAGE-3 protein.Conclusion MAGE-3 protein is expressed at a high frequency in NSCLC samples,and it may be the suitable vaccine material for immunotherapy for NSCLC patients. |
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| Keywords: | Lung neoplasms MAGE-3 protein Immunotherapy Flow cytometry(FCM) |
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