| 山莨菪碱对脑血管内皮细胞与自由基的影响 |
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| 引用本文： | 毛小平 钟萍. 山莨菪碱对脑血管内皮细胞与自由基的影响[J]. 微循环学杂志, 1996, 6(4): 15-16 |
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| 作者姓名： | 毛小平 钟萍 |
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| 作者单位： | 湖北医科大学附属第一医院，东风汽车集团公司花果医院内科 |
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| 摘 要： | 采用电子显微镜观察沙鼠急性缺血再灌注后内皮细胞的变化及山莨菪碱对其的作用，结果发现缺血再灌注组脑血管内皮细胞间隙增宽，紧密连接破坏，采用电子顺磁共振法测定自由基单位重量积分强度为５２９２１．１４２±２．７６５；山莨菪碱组脑血管内皮细胞损伤明显减轻，并且自由基单位重量积分强度为３５５６２．９２６±８．１３７（Ｐ＜０．０５）。说明山莨菪碱能够保护脑血管内皮细胞和具有清除氧自由基作用
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| 关 键 词： | 脑再灌注损伤 血管内皮细胞 自由基 山莨菪碱 沙土鼠 |
Effect of Free Radicals and Cerebrovascular Endothelial Cell in Post Ischemic Injury by Anisodamines |
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| Mao Xiaoping,Gong Meifang,Zhong Ping/First Affiliated Hospital of Hubei Medical University,Wuhan. Effect of Free Radicals and Cerebrovascular Endothelial Cell in Post Ischemic Injury by Anisodamines[J]. Chinese Journal of Microcirculation, 1996, 6(4): 15-16 |
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| Authors: | Mao Xiaoping Gong Meifang Zhong Ping/First Affiliated Hospital of Hubei Medical University Wuhan |
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| Affiliation: | Mao Xiaoping,Gong Meifang,Zhong Ping/First Affiliated Hospital of Hubei Medical University,Wuhan 430060 |
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| Abstract: | The role of free radicals and cerebrovascular endothelial cell in post ischemic injury is studied. The brain ischemia reperfusion model was produced in mongolian gerbil. Free radicals determination by ESR, ultrastructural observation by electron microscopy. Results showed that anisodamine treated reperfusion group showed improvement in cerebrovascular endotheliocytic lesion as compared to untreated reperfusion group; that free radicals levels were significantly decreased in anisodamine treated repeifusion group as compared to untreated reperfusion ( P < 0.05 ). |
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| Keywords: | Post ischemic injury brain Endothelial cell cerebrovascular Free radicals Anisodamine |
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